A Nonsense Mutation In Gsdmc Is Associated With Cancer Mortality In Dogs

Author

Hang LiFollow

Date of Award

January 2022

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Josephine Hoh

Abstract

Over 400 distinct canine breeds today were result from artificial selection during the last centuries. And due to the selection pressure from human interest and the founder effects, the difference among individual genomes from one same breed is less than the difference between breeds. 446 samples were included in this study to recognize the cancer-associated nonsense mutations in canine genome. 17 of the 446 samples were lab-recruited dogs, and the other 429 samples were downloaded from Sequence Read Archive. One nonsense mutation in GSDMC protein is found significantly associated with cancer risk in dogs. Since nonsense mutations could provide premature proteins or shortened mRNA lifespan, given that the potential function of GSDMC in cell death pathways, our study results provide clues for pathological function of GSDMC in cancer.

Comments

This is an Open Access Thesis.

Recommended Citation

Li, Hang, "A Nonsense Mutation In Gsdmc Is Associated With Cancer Mortality In Dogs" (2022). Public Health Theses. 2175.
https://elischolar.library.yale.edu/ysphtdl/2175