Date of Award

1-1-2023

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Elizabeth Claus

Abstract

PURPOSE: It is unclear what role sociodemographic predictors have on the subtype-specific survival patterns of patients with low-grade gliomas. Understanding these effects may help guide and improve public health intervention strategies for patients with this relatively rare, understudied condition. METHODS: Using the Surveillance, Epidemiology, and End Results Program, we identified adult cases (aged 20-79 years) diagnosed with a World Health Organization Central Nervous System grade II supratentorial astrocytoma, oligodendroglioma, or mixed glioma between 1975-2019. Kaplan-Meier estimates and multivariable Cox models were utilized to assess factors associated with survival. RESULTS: The final cohort included 4,684 adult grade II glioma cases with a median survival of 5.7 (95% confidence interval [CI]: 5.3-6.1) years. Approximately 10% of patients diagnosed in 1975-1994 survived at least 25 years. The median survival for oligodendroglioma, mixed glioma, and astrocytoma patients was 13.7 (95% CI: 12.7-14.9), 9.3 (95% CI: 7.9-10.5), and 2.5 (95% CI: 2.3-2.8) years, respectively (log-rank p

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