Date of Award

January 2022

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Melinda Pettigrew

Second Advisor

James Teufel

Abstract

This study aims to identify potential discrepancies between the racial/ethnic demographics of participants enrolled in randomized controlled trials of antibacterials used to treat Staphylococcus aureus and the demographics for those who contract the disease. 115 clinical trials were analyzed for gender, racial, and ethnicity of clinical trial participants. Of the included studies, 95.7% included data on gender, 71.3% included racial data, and 27.0% included ethnicity data. Black/African American individuals were substantially underrepresented in trials when compared to the burden of disease that they share. Black/African American representation in S. aureus clinical trials needs to be ensured in order to properly investigate clinical efficacy of new antibiotics. Ethnicity data should be gathered by researchers on all clinical trials. A standard reporting method for race/ethnicity needs to be implemented for clinical trials to ensure comparability and to allow for analysis on more specific racial/ethnic groups

Comments

This is an Open Access Thesis.

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