Date of Award

January 2021

Document Type

Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Albert Ko

Abstract

We explored the serologic responses post-SARS CoV-2 infection and anti-SARS CoV-2 Spike protein (S1) IgG and IgM kinetics. Blood plasma anti- S1 antibody responses in 16 Healthcare Workers (HCWs) who tested positive for SARS-CoV-2 by RT-PCR was measured over a follow-up period of up to 250 days post-first PCR positive. These were compared to the responses in 80 individuals whose blood samples were obtained prior to the pandemic. 11 (68.75%) of these HCWs showed detectable antibody responses post infection. Age, sex, race/ethnicity, BMI, and clinical presentation had no significant association with seroconversion. Seroconversion in this cohort was observed after a median time of 15 days post first PCR positive, with no significant association with clinical presentation. Although anti-S1 IgG response decayed slowly, with only 3 individuals seroreverting in the follow-up period, interval-censored nonparametric model estimates of time suggested that waning of antibodies takes marginally longer in symptomatic HCWs than in those who were asymptomatic. In conclusion, our study showed no significant association between clinical presentation and antibody kinetics post SARS CoV-2 infection.

Comments

This thesis is restricted to Yale network users only. This thesis is permanently embargoed from public release.

Download

Share

COinS