Date of Award

January 2021

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Yong zhu

Abstract

The circadian rhythm controls a range of important biological behaviors with a 24-hour cycle. The mammalian biological clock is a layered network of vibrators with a master clock locating in the neurons of suprachiasmatic nucleus (SCN) in the hypothalamus and a set of core and related circadian genes. Several lines of evidence from previous studies suggested the relationships between tumorigenesis and circadian rhythm disruption. However, the effects of circadian genetic factors in cancer survival remains uncertain. Therefore, it is important to review and explore the circadian genetic factors which might be linked to cancer survival. This paper aimed to evaluate the potential associations between circadian genetic factors and cancer survival by summarizing 30 epidemiological studies and searching 2 databases. The circadian genetic factors identified included both gene expression and SNPs. Our results showed that 16 circadian genes, PER1, PER2, PER3, CRY1, CRY2, BMAL1, CLOCK, NPAS2, NPAS3, TIMELESS, RORA, RORC, NR1D2, CK1ε, DEC1 and TIPIN, were significantly related to cancer survival across several types of cancer. The associations between circadian genes and cancer survival differed among different genes and cancer types.

Comments

This is an Open Access Thesis.

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