Date of Award

Summer 6-16-2023

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Suguru Imaeda, MD


Skin exposure to ultraviolet (UV) irradiance is the major cause of skin disorders, such as sunburn and nonmelanoma cancer. The current standard of care for photoprotection is the daily use of sunscreen, although patient adherence and adequate application continues to be an issue. Current data show systemic photoprotection can be added to sunscreen use to reduce the risk of cutaneous diseases. This randomized controlled study will investigate whether supplementation with Polypodium leucotomas versus carotenoid supplementation versus the standard of care, provide increased photoprotection in adults with Fitzpatrick skin types II-IV. Outcomes will be measured by comparing the minimal erythema dose before and after treatment. We hypothesize the treatment group receiving oral Polypodium leucotomas will have a higher minimal erythema dose compared to the other groups. The results of this study will help inform photodamage prevention with the goal of reducing the risk of developing UV-carcinogenesis and erythema in the skin.

Open Access

This Article is Open Access