Comparison of Oral Carotene Supplementation and Oral Polypodium Leucotomas in Preventing Photodamage
Date of Award
Summer 6-16-2023
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
Suguru Imaeda, MD
Abstract
Skin exposure to ultraviolet (UV) irradiance is the major cause of skin disorders, such as sunburn and nonmelanoma cancer. The current standard of care for photoprotection is the daily use of sunscreen, although patient adherence and adequate application continues to be an issue. Current data show systemic photoprotection can be added to sunscreen use to reduce the risk of cutaneous diseases. This randomized controlled study will investigate whether supplementation with Polypodium leucotomas versus carotenoid supplementation versus the standard of care, provide increased photoprotection in adults with Fitzpatrick skin types II-IV. Outcomes will be measured by comparing the minimal erythema dose before and after treatment. We hypothesize the treatment group receiving oral Polypodium leucotomas will have a higher minimal erythema dose compared to the other groups. The results of this study will help inform photodamage prevention with the goal of reducing the risk of developing UV-carcinogenesis and erythema in the skin.
Recommended Citation
Martinez, Jazmin, "Comparison of Oral Carotene Supplementation and Oral Polypodium Leucotomas in Preventing Photodamage" (2023). Yale School of Medicine Physician Associate Program Theses. 183.
https://elischolar.library.yale.edu/ysmpa_theses/183
