Date of Award

Spring 4-21-2023

Document Type

Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Anil Nagar, MD

Abstract

Gastroparesis is a condition of delayed gastric emptying leading to chronic upper abdominal pain, bloating, nausea, and vomiting. Management of gastroparesis is difficult because non-operative treatments often fail to produce lasting improvements in symptoms or functional status.

One novel treatment option for gastroparesis is gastric peroral endoscopic myotomy, a minimally invasive endoscopic procedure that offers greater rates of clinical success than present treatments. However, there are no objective metrics that can predict which patients will have the best outcomes after the procedure.

In this randomized controlled trial, we will determine whether a guided myotomy, using endoscopic functional luminal imaging probe metrics, will offer higher rates of clinical success than clinician judgment alone in patients with refractory gastroparesis. This study will advance the body of knowledge on this increasingly prevalent condition, which can help alleviate the high morbidity and psychological stress patients with gastroparesis experience.

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