Date of Award

7-29-2022

Document Type

Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Saber Ghiassi, MD, MPH, FACS

Abstract

Gastroesophageal reflux disease, a disorder in which stomach contents backflow into the esophagus, is common in patients who have undergone sleeve gastrectomy surgery for weight loss. Sleeve gastrectomy patients who experience gastroesophageal reflux disease are typically treated with acid-suppression medications, namely proton pump inhibitors, and a subset will undergo surgical conversion to Roux-en-Y gastric bypass. However, long-term effects of these treatments on quality of life are under-studied in these patients. We propose to study the impact of gastric bypass conversion and treatment with proton pump-inhibitors on quality of life in patients with gastroesophageal reflux disease after sleeve gastrectomy. Using a prospective cohort study design, we will recruit patients with post-sleeve gastrectomy gastroesophageal reflux and assess quality of life using the validated Gastroesophageal Reflux Disease-Health Related Quality of Life questionnaire at 1-year post-intervention. The findings will inform the therapeutic decisions of providers caring for sleeve gastrectomy patients with gastroesophageal reflux disease.

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