Date of Award
7-1-2021
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
Kevin Sheth, MD
Abstract
Intracranial aneurysms are a common vascular abnormality identified incidentally or after rupture leading to aneurysmal subarachnoid hemorrhage. However, accurately assessing the risk of aneurysmal disease progression is challenging. Here we propose a prospective cohort study to identify if elevated levels of matrix metalloproteinase-9, a molecular marker of vascular degeneration, in the peripheral blood samples of subjects with unruptured intracranial aneurysms correlate with aneurysm progression over a follow up period. This study aims to aid in identifying patients at increased risk of aneurysm progression in order to guide treatment decisions and ultimately decrease subarachnoid hemorrhage morbidity and mortality.
Recommended Citation
Stampfel, Peter, "The Effect of Plasma Levels of Matrix Metalloproteinase-9 on Intracranial Aneurysm Progression" (2021). Yale School of Medicine Physician Associate Program Theses. 107.
https://elischolar.library.yale.edu/ysmpa_theses/107
