Date of Award

January 2024

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Eyiyemisi Damisah

Abstract

We sought to understand the role of the human claustrum at the single neuron level during slow-wave sleep. Using intracranial recordings from microwires and macroelectrode contacts, we correlated the activity of the claustrum with multiple measures of slow-wave sleep. In stark contrast to neurons in the anterior cingulate cortex and amygdala, neurons in the claustrum increased their firing rate at the beginning of NREM sleep, maintained an increased firing rate through the duration of NREM sleep intervals, and decreased their firing rate during the transition out of NREM sleep. These findings build upon causal experimental studies in animals demonstrating the crucial role of the claustrum in coordinating slow-waves during NREM sleep.

Comments

This thesis is restricted to Yale network users only. This thesis is permanently embargoed from public release.

Download

Share

COinS