Date of Award

January 2023

Document Type


Degree Name

Medical Doctor (MD)



First Advisor

Michael Bloch


Introduction: Borderline personality disorder is a distressing condition defined in the DSM-5- TR as meeting five of nine criteria around impulsivity and instability in mood, identity, and relationships. While there have been other meta-analyses examining the efficacy of pharmacological interventions for the condition, this is the first network meta-analysis. Methods: We searched PubMed, Embase, and Cochrane. We screened articles at the abstract and then full-text stage. After extracting the data, we used the ‘netmeta’ R-package to conduct network meta-analyses.Results: We found that brexpiprazole, aripiprazole, and topiramate each outperformed placebo for at least one outcome. However, only 38% of trials reported usable data for overall borderline personality disorder symptomatology, 53% for depression symptoms, 23% for anxiety symptoms, and 35% for global functioning/global psychopathology. Discussion: It is imperative that future research reach a consensus on which outcomes are important to include when assessing the efficacy of pharmacological interventions for borderline personality disorder.


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