Date of Award

January 2023

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Michael Bloch

Abstract

Introduction: Borderline personality disorder is a distressing condition defined in the DSM-5- TR as meeting five of nine criteria around impulsivity and instability in mood, identity, and relationships. While there have been other meta-analyses examining the efficacy of pharmacological interventions for the condition, this is the first network meta-analysis. Methods: We searched PubMed, Embase, and Cochrane. We screened articles at the abstract and then full-text stage. After extracting the data, we used the ‘netmeta’ R-package to conduct network meta-analyses.Results: We found that brexpiprazole, aripiprazole, and topiramate each outperformed placebo for at least one outcome. However, only 38% of trials reported usable data for overall borderline personality disorder symptomatology, 53% for depression symptoms, 23% for anxiety symptoms, and 35% for global functioning/global psychopathology. Discussion: It is imperative that future research reach a consensus on which outcomes are important to include when assessing the efficacy of pharmacological interventions for borderline personality disorder.

Comments

This thesis is restricted to Yale network users only. This thesis is permanently embargoed from public release.

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