Date of Award
1-1-2020
Document Type
Open Access Thesis
Degree Name
Medical Doctor (MD)
Department
Medicine
First Advisor
Keith A. Choate
Abstract
Abstract: THE DEVELOPMENT AND VALIDATON OF A NOVEL ICHTHYOSIS SEVERITY ASSESSMENT INSTRUMENT. Qisi Sun, Amy Paller, Keith A. Choate. Department of Dermatology, Genetics & Pathology, Yale University School of Medicine, New Haven, CT.
Ichthyosis clinical trials require reliable, validated severity assessments to identify appropriate subjects and quantify treatment outcomes. There is no validated scale to measure ichthyosis severity across the entire body. We aim to create and validate a comprehensive and user-friendly instrument to measure total body ichthyosis severity in adults and children.We divided the body into 10 regions to score special regions of interest. Likert scales (0-4) were established to quantify scale and erythema, with descriptors and photographic standards. An 83-image teaching set was created from photographs of ichthyosis patients, Six dermatologists scored all test photographs twice to evaluate intra-rater reliability. Intra-class correlation coefficients (ICCs) determined the overall reliability of our instrument.
The ICC for combined scale and erythema scores across the entire body is 0.903 (95% CI, 0.77-0.974). ICCs for scale and erythema sub-scores are 0.911 (95% CI, 0.789-0.976) and 0.882 (95% CI, 0.723-0.968), respectively. Body sites exhibited moderate-good inter-rater reliabilities for scale, except elbows and lower extremities. Erythema reliabilities across all body sites were moderate-excellent. Intra-rater reliabilities were excellent (ICC >0.9).The ISS is validated as a comprehensive tool for assessing ichthyosis severity across the entire body.
Recommended Citation
Sun, Qisi, "The Development And Validation Of A Novel Ichthyosis Severity Assessment Instrument" (2020). Yale Medicine Thesis Digital Library. 4034.
https://elischolar.library.yale.edu/ymtdl/4034