Date of Award

1-1-2018

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Oscar R. Colegio

Abstract

This study demonstrates how PDVC57 is an effective pre-clinical model to test immunomodulatory medications for cutaneous SCC in immunocompetent C57Bl/6 mice. We demonstrated the first analysis of myeloid populations within the cutaneous SCC tumor microenvironment and found increased Arg1 expression in TAMs. TAM-inhibition using topically delivered Nor-NOHA effectively decreased tumor size and represents a promising new modality to potentially treat cutaneous SCC. Further clinical trials are warranted to test nor-NOHA in patients with cutaneous SCC and to determine if monotherapy or combination with checkpoint inhibition is more effective.

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