Date of Award

1-1-2018

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Igor Latich

Abstract

Purpose

To evaluate the effectiveness of pre-procedural single-dose IV antibiotics during port placement in preventing procedure-related infections, and to identify clinical and technical contributing factors.

Material and methods

This was a single-institution, IRB-approved study evaluating short-term (30-day) infection outcomes after the placement of a chest port. Correlation between infection rate and clinical factors, including hematologic vs. non-hematological malignancy, in-patient vs. outpatient status, and administration of prophylactic pre-procedural IV antibiotics was investigated. Additionally, correlation between infection rate and technical factor such as device type (single vs. double lumen) was evaluated. Chi-squared and Fisher exact tests were used for statistical analysis where applicable.

Results

Overall, 5,967 ports were placed between 2005 and 2016. Of the 3,978 (67%) patients who received prophylactic antibiotics, 94% (3,757/3,978) received cefazolin. Port removal due to infection concern was performed in 48 patients, with no statistically significant difference in the rate of infection between those who received antibiotics (0.85%, 34/3,978) vs. those who did not (0.70%, 14/1,989; p=0.5387). There was a statistically significant higher rate of infection in patients who had their port placed as an inpatient (p

Conclusion

Single dose of pre-procedural antibiotics does not appear to prevent short-term procedure-related infections.

Download

Share

COinS