The effect of salicylate and chloroquine on prostaglandin-induced articular damage in the rabbit knee

Author

Carol C. Teitz, Yale University

Date of Award

1974

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Dr. O. Donald Chrisman

Abstract

[From the Discussion] In summary, we have shown that prostaglandin E1, when injected in the rabbit knee produces synovitis and cartilage matrix degradation. The finding that salicylate cannot prevent this degeneration whereas chloroquine can, is most likely due to their different mechanisms of action in this system. Whereas chloroquine's ability to stabilize membranes is protective int his experiment, salicylate's ability to prevent the biosynthesis of prostaglandins is by passed and therefore is not.

Comments

This is an Open Access Thesis

Recommended Citation

Teitz, Carol C., "The effect of salicylate and chloroquine on prostaglandin-induced articular damage in the rabbit knee" (1974). Yale Medicine Thesis Digital Library. 3240.
https://elischolar.library.yale.edu/ymtdl/3240