Abstract

The total cobamide concentration (vitamin B12 plus B12 analogs active for some organisms) can be determined in sea water by bioassay utilizing growth of the centric diatom Bellerochea polymorpha clone 675-d. Vitamin B12 activity can be determined by bioassay utilizing Thalassiosira pseudonana clone 3H; hence the activity of vitamin B12 analogs can be determined by difference....

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