Date of Award
Spring 2022
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Mayer, James
Abstract
This thesis aims to advance our understanding of H-atom transfer processes at carbon-centered radicals. First, we develop a robust synthetic route towards accessing triphenylmethyl (trityl) radicals as tools for studying radical reactions at carbon, among other things. Then, we utilize trityl radicals to assess the intrinsic reactivity at C–H bonds. The final chapter of this thesis provides details into the design and synthesis of a series of (+)–pleuromutilin analogs. Several iterations of hydrindane-core-modified and peripherally-functionalized pleuromutilins are addressed.
Recommended Citation
Heuer, Abigail Marie, "Kinetic and Thermodynamic Studies of Triphenylmethyl Radicals" (2022). Yale Graduate School of Arts and Sciences Dissertations. 977.
https://elischolar.library.yale.edu/gsas_dissertations/977
