Date of Award
Fall 2022
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Hazari, Nilay
Abstract
This thesis summarizes work towards the development of new methods for the construction of C-C bonds through Ni-catalyzed cross-coupling reactions of nontraditional electrophiles and dual-catalytic cross-electrophile coupling reactions. Chapter 1 presents an introduction to Ni-catalyzed cross-coupling and cross-electrophile coupling reactions. Chapter 2 details the development and mechanistic study of a new Ni precatalyst for Suzuki-Miyaura cross-coupling reactions involving aryl carbonates. Chapter 3 describes a Ni/Co dual-catalytic strategy for cross-electrophile coupling and provides an exploration of the scope of the method, including its compatibility with pharmaceutically relevant substrates. Chapter 4 describes progress toward the development of a Ni/Ti dual catalytic cross-electrophile coupling method that was designed by exploring the reactivity of low-valent Ti complexes in a model hydrogen atom transfer reaction.
Recommended Citation
Barth, Emily Lucille, "Nickel Catalyzed Cross-Coupling and Cross-Electrophile Coupling Reactions for the Construction of New C-C Bonds" (2022). Yale Graduate School of Arts and Sciences Dissertations. 857.
https://elischolar.library.yale.edu/gsas_dissertations/857
