Date of Award

January 2023

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Yong Zhu

Second Advisor

Kai Chen

Abstract

Organisms exhibit rhythmic fluctuations in their behavior and metabolism every 24 hours, a phenomenon controlled by their circadian clock to anticipate changes in the environment. In the past forty years, substantial progress has been made in our knowledge of the molecular mechanisms underlying the circadian clock and cancer. In this context, researchers have explored the possibility of leveraging the circadian clock to improve cancer treatment. Several randomized controlled trials have investigated the effects of circadian chemotherapy and radiotherapy on drug toxicity and efficacy, with many studies reporting clinically significant outcomes, although some findings remain inconsistent. This mini review aims to summarize the current state of research on chronotherapy in oncology by examining the results of randomized controlled trials investigating chemotherapy and radiotherapy. The goal is to provide an overview of the potential of chronotherapy in the tumor field and to highlight areas where further investigation is needed.

Comments

This is an Open Access Thesis.

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