"Cardiovascular Outcomes In Hypertension As Defined By Proof-Bp Using N" by Kamran Javadi

Date of Award

January 2020

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Catherine Yeckel

Second Advisor

Rosana Gonzalez-Colaso

Abstract

Hypertension is one of the most common medical conditions, affecting nearly one-third of Americans.1 Chronic high blood pressure is the cause of numerous cardiovascular diseases which cost the United States over $100 billion annually.1 The American College of Cardiology and American Heart Association have recently challenged the previous definition of hypertension by suggesting those with a blood pressure of ≥130/80 mmHg now have the disease.2 This new threshold would classify nearly 50% of Americans as hypertensive.2 Establishing a diagnosis of hypertension can be difficult and resource intensive requiring patients to have serial recordings over 24-hours. Until recently there has been no reliable strategy for indexing the 24-hour ambulatory blood pressure in the clinic. This thesis used the Proof-BP algorithm along with traditional Clinic BP measurements to analyze MI, stroke, and CHF prevalence in hypertensive NHANES participants. Additionally, the sensitivity, specificity, and predictive values of Proof-BP and Clinic BP were calculated. Based on the findings of this study, Proof-BP may be advantageous at assessing cardiovascular prevalence in certain groups. Due to its high specificity and negative predictive value, Proof-BP provides a reliable method of ruling out cardiovascular disease in healthy populations. Importantly, Proof-BP allows for detection of white coat hypertension and masked hypertension, both of which are impossible to detect from a single blood pressure measurement.

Comments

This is an Open Access Thesis.

Open Access

This Article is Open Access

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