Date of Award
Master of Public Health (MPH)
School of Public Health
Ethnic differences in the risk of early-onset Hodgkin lymphoma (HL) have been understudied. We evaluated potential associations between birth characteristics and early-onset HL in the California Linkage Study of Early-onset Cancers, a population-based case-control study that included a large number of non-Hispanic white and Hispanic subjects. This analysis included 2,819 HL cases (non-Hispanic white: 1651, Hispanic: 1168) diagnosed at the age of 0-37 years in California during 1988-2015 and 140,950 controls matched on race/ethnicity and year of birth. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression models. Among non-Hispanic whites, a birthweight of ≥4,000g was associated with an increased risk of HL when compared to normal birthweight (2500-3999g) (OR = 1.25, 95% CI: 1.10, 1.43), while low birthweight (<2500g) decreased the risk (OR = 0.63, 95% CI: 0.48, 0.83). High or low birthweight did not appear to influence HL risk in Hispanics. Compared to those with mothers born in the United States, non-Hispanic whites with mothers born outside the United States had an increased risk of HL (OR = 1.52, 95% CI: 1.32, 1.76), but Hispanics with mothers born outside the United States had a decreased risk of HL (OR = 0.78, 95% CI: 0.69, 0.87). Given the ethnic differences in the etiology of early-onset Hodgkin lymphoma that we observed in this study, future research in diverse populations is warranted.
Graham, Connor Ashton, "Ethnic Differences And Risk Of Early-Onset Hodgkin Lymphoma" (2020). Public Health Theses. 1941.