Date of Award

January 2020

Document Type

Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Xiaomei Ma

Abstract

Ethnic differences in the risk of early-onset Hodgkin lymphoma (HL) have been understudied. We evaluated potential associations between birth characteristics and early-onset HL in the California Linkage Study of Early-onset Cancers, a population-based case-control study that included a large number of non-Hispanic white and Hispanic subjects. This analysis included 2,819 HL cases (non-Hispanic white: 1651, Hispanic: 1168) diagnosed at the age of 0-37 years in California during 1988-2015 and 140,950 controls matched on race/ethnicity and year of birth. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression models. Among non-Hispanic whites, a birthweight of ≥4,000g was associated with an increased risk of HL when compared to normal birthweight (2500-3999g) (OR = 1.25, 95% CI: 1.10, 1.43), while low birthweight (<2500g) decreased the risk (OR = 0.63, 95% CI: 0.48, 0.83). High or low birthweight did not appear to influence HL risk in Hispanics. Compared to those with mothers born in the United States, non-Hispanic whites with mothers born outside the United States had an increased risk of HL (OR = 1.52, 95% CI: 1.32, 1.76), but Hispanics with mothers born outside the United States had a decreased risk of HL (OR = 0.78, 95% CI: 0.69, 0.87). Given the ethnic differences in the etiology of early-onset Hodgkin lymphoma that we observed in this study, future research in diverse populations is warranted.

Comments

This thesis is restricted to Yale network users only. It will be made publicly available on 05/27/2022

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