Date of Award

1-1-2019

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Shi-Yi Wang

Abstract

INTRODUCTION: To evaluate the influence of marital status on the survival outcomes of patients diagnosed with parathyroid cancer.

MATERIALS and METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients diagnosed with parathyroid cancer between 1975 and 2016. Survival analysis was performed using Kaplan-Meier method and multivariate Cox regression analysis, to evaluate the association between marital status and parathyroid cancer survival, controlling for potential confounders. Overall mortality and parathyroid cancer-specific mortality rates were calculated for 5-year and 10-year follow-up periods.

RESULTS: The final cohort from SEER consisted of 611 patients. 373 (61.05%) were married and 238 (38.95%) were unmarried. 315 were male (51.55%) and 286 were female (48.45%). Married patients were older (Mean age 56.98 years; 95% CI 55.66-58.31) compared to unmarried patients (Mean age 54.72 years; 95% CI 52.69-56.75). Married patients had better overall 5-year survival (94.3% vs 86.4%; p=0.0532), and better overall 10-year survival (86.4% vs 72.2%; p=0.0061). Marital status was not associated with cancer-specific survival. Older age at diagnosis (HR 1.62; p=0.0254), distant metastases (HR 2.75; p

CONCLUSIONS: Marital status is an independent predictor of 10-year overall survival in patients with parathyroid cancer. It is not a statistically significant independent predictor for parathyroid cancer specific survival.

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This is an Open Access Thesis.

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