Complications of Bone Morphogenetic Protein-2 Use in Open Transforaminal Lumbar Interbody Fusion
Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Arya Varthi, MD
Transforaminal Lumbar Interbody Fusion is commonly performed with the use of off-label recombinant human bone morphogenetic protein-2. Despite its widespread use, bone morphogenetic protein-2 has been linked with postoperative complications in observational studies. However, no experimental study has supported this association nor has the relative risk as compared to iliac crest bone graft been quantified. In this study, we will compare the incidence proportion of radiculopathy, heterotopic ossification, and vertebral endplate osteolysis following Transforaminal Lumbar Interbody Fusion in patients who receive recombinant human bone morphogenetic protein-2 versus patients who receive iliac crest bone graft. Specifically, we will carry out a single-blinded, randomized controlled trial to assess incidence through six months of follow-up. The insights gathered will guide patient and surgeon decisions as they weigh the risks of different graft materials.
Miller, Allison, "Complications of Bone Morphogenetic Protein-2 Use in Open Transforaminal Lumbar Interbody Fusion" (2021). Yale School of Medicine Physician Associate Program Theses. 85.
This Article is Open Access