Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Patrick G. O’Connor, MD, MPH, FACP
During the current opioid crisis, hospitalizations for the treatment of intravenous drug use-related infective endocarditis have increased. Despite this, opioid use disorder is inadequately treated resulting in continued drug use, higher surgical intervention, recurrence and mortality rates relative to non-drug use-related endocarditis. Buprenorphine* is a safe and effective medication-assisted addiction treatment in outpatient settings; however, buprenorphine remains underutilized, particularly among patients hospitalized for infective endocarditis. Emergency department-initiated buprenorphine combined with referral to ongoing treatment is associated with improved rates of addiction treatment engagement. Therefore, our objective is to investigate whether hospital-initiated buprenorphine combined with referral in patients with opioid use disorder admitted for infective endocarditis is more effective than referral alone for treatment engagement 30 days post-hospital discharge. These results may optimize our standard of care for patients with intravenous drug use-associated infective endocarditis to enhance enrollment in treatment for opioid use disorder.
Cheung, Naiska Y., "Initiating Buprenorphine in Patients Hospitalized with Intravenous Drug-Use-Related Endocarditis" (2019). Yale School of Medicine Physician Associate Program Theses. 50.
This Article is Open Access