Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Jason Sico, MD, MHS


Stroke patients who lose the ability to produce language (aphasia) often remain able to sing. This observation has stimulated interest in a structured music therapy, Melodic Intonation Therapy, for post-stroke aphasia. While existing studies find positive outcomes with Melodic Intonation Therapy, its efficacy has yet to be substantiated by adequately powered, randomized, controlled trials. Focusing on acute stroke patients, we aim to determine the impact of melodic intonation therapy versus usual care on aphasia recovery. The study will be a single blind, randomized controlled trial with modified melodic intonation therapy and usual care groups. Aphasia severity will be scored at baseline and 3 weeks, and the mean difference from baseline will be compared across groups. Post-stroke aphasia has high morbidity and mortality and profoundly impedes daily living. Its rehabilitation is imperative. In the absence of standard of care, my results may inform early treatment options that can enhance recovery.

Open Access

This Article is Open Access