Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Emily J. Gilmore, MD, FNCS, FACNS


Traumatic brain injury is a significant cause of death and disability and accounts for 16% of injury-related emergency department visits in the United States. Current guidelines for management of traumatic brain injury are focused on identifying and preventing secondary brain injury using multimodal invasive monitoring techniques, including cerebral oxygenation monitoring. However, these approaches have risks and there is currently no clinical consensus that use of invasive monitoring improves patient functional outcome. We will evaluate whether noninvasive monitoring of cerebral oxygenation with near infrared spectroscopy can reduce the median duration of brain tissue hypoxia in patients with severe traumatic brain injury. Specifically, we will determine whether this method has benefit in combination with current guidelines, versus management based on current guidelines alone. This study will provide evidence that noninvasive cerebral oxygenation monitoring is a physiologic parameter that may modify interventions to direct targeted treatments and improve outcomes in traumatic brain injury.

Open Access

This Article is Open Access