Date of Award

7-31-2020

Document Type

Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Samuel Wilkinson, MD

Abstract

Depression is a prevalent disorder that is associated with decreased quality of life and increased mortality. Despite pervasive and disabling symptoms, effective treatment options are sparse. Neuromodulating therapies, such as transcranial magnetic stimulation, have shown to be efficacious for treating depression but are limited by high rates of relapse. Cognitive behavioral therapy has been suggested as a potential additive to neuromodulating therapies to sustain the antidepressant effect. However, no large randomized trials to date have tested the combination of transcranial magnetic stimulation and cognitive behavioral therapy. Using a randomized controlled trial, this study will examine the efficacy of transcranial magnetic stimulation in combination with cognitive behavioral therapy on relapse of depression. The results of this study may offer clinicians a tool to foster long-term relief for patients suffering with depression.

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