Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Clemente Britto-Leon, MD
Cystic fibrosis is a genetic disorder that impairs mucus clearance in the lungs, causing chronic inflammation and recurrent infections. Several airway clearance modalities are recommended to improve or preserve lung function, including chest percussion and exercise. However, there is no clinical consensus on the best treatment regimen to maximize the effect of airway clearance therapies and exercise. The purpose of this study is to determine whether a structured order of exercise and airway clearance therapy improves lung function. Using a randomized study, we will evaluate the effectiveness of a structured regimen compared to a non-structured regimen by following lung function over one year. Upon completion, we expect the structured program will result in improved lung function when compared to the non-structured program. Our results may benefit cystic fibrosis patients by informing the adoption of structured exercise and airway clearance practices to improve lung function and quality of life.
Rose, Rachel, "A Structured Airway Clearance and Exercise Program to Improve Clinical Outcomes in Cystic Fibrosis" (2020). Yale School of Medicine Physician Associate Program Theses. 29.
This Article is Open Access