Date of Award

6-19-2020

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Clemente Britto-Leon, MD

Abstract

Cystic fibrosis is a genetic disorder that impairs mucus clearance in the lungs, causing chronic inflammation and recurrent infections. Several airway clearance modalities are recommended to improve or preserve lung function, including chest percussion and exercise. However, there is no clinical consensus on the best treatment regimen to maximize the effect of airway clearance therapies and exercise. The purpose of this study is to determine whether a structured order of exercise and airway clearance therapy improves lung function. Using a randomized study, we will evaluate the effectiveness of a structured regimen compared to a non-structured regimen by following lung function over one year. Upon completion, we expect the structured program will result in improved lung function when compared to the non-structured program. Our results may benefit cystic fibrosis patients by informing the adoption of structured exercise and airway clearance practices to improve lung function and quality of life.

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