Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Sean Christensen, MD, PhD
Penile intraepithelial neoplasia is a rare malignant lesion commonly caused by the human papillomavirus or associated with lichen sclerosus. The definitive treatment for these indolent lesions is surgery, however topical treatments are often first line as an organ-preserving strategy. Currently, the evidence for topical therapies is based on literature reviews and case studies, with no randomized trials to best guide treatment. In this study, we will conduct a double-blind, randomized placebo-controlled trial to determine whether the use of imiquimod 5% cream as a primary therapy will have higher complete response rates in penile intraepithelial neoplasia compared to placebo cream prior to definitive Mohs micrographic surgery. This study would provide robust evidence for the use of imiquimod as a monotherapy, as well as additional data on recurrence rates and the efficacy of Mohs micrographic surgery.
Miller, Joseph, "Topical Imiquimod as Primary Therapy Prior to Mohs Surgery for Penile Intraepithelial Neoplasia" (2020). Yale School of Medicine Physician Associate Program Theses. 26.
This Article is Open Access