Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Samantha Smith, MD


Medial collateral ligament tears are the most common knee ligament injury. Extent of injury is graded on a three-point scale. The mainstay of treatment for isolated tears is physical therapy; however, grade II and III tears require more intensive therapy. Platelet-rich plasma therapy is an autologous concentration of platelets prepared as an injection to augment the healing process. We propose a randomized controlled trial investigating the efficacy of platelet-rich plasma injection for patients with acute grade II or III medial collateral ligament tears. Results will be quantified by mean decrease in Visual Analog Scale scores at two, four, and six weeks. We hypothesize that injection of platelet-rich plasma combined with physical therapy will significantly decrease pain scores when compared to standard physical therapy. This study will evaluate a new treatment for acute isolated grade II and III medial collateral ligament tears in decreasing pain and expediting return to activity.

Open Access

This Article is Open Access