Date of Award
Summer 8-25-2023
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
James Clune, MD
Abstract
Background: Current guidelines recommend SLN biopsy (SLNB) among patients with initial Breslow Thickness (BRES) ≥0.8mm at initial screening. However, there is limited guidance regarding SLNB among patients who have deeper final depth after initial biopsy.
Methods: We conducted a retrospective cohort study of 62 thin melanoma patients with primary lesions with initial Breslow Thickness (BRES)
Results: Approximately 55% of patients (n = 34) included in our study underwent SLNB. After adjustment, there was no association between SLNB status and recurrence. Immunosuppressive drug use was associated with higher odds of local (OR= 28.56 CI 1.87- 435.53; p =0.016) and regional recurrence (OR= 28.55 CI 1.5–542.50; p =0.016). Smoking was also associated with higher odds of regional recurrence (OR= 18.48 CI 1.37-249.15; p =0.028). Lymphocytic infiltrate was associated with lower odds of regional (OR= 0.05 CI 0.004-0.70; p =0.03) and distant (OR= 0.97 CI 0.01–0.71; p =0.02) recurrence.
Conclusions: Among patients with initial Breslow Thickness (BRES)
Recommended Citation
Souza Cunha, Ana Eliza, "Decision Making in Patients with Initial Positive Deep Margins on Diagnostic Biopsy of Melanoma" (2023). Yale School of Medicine Physician Associate Program Theses. 194.
https://elischolar.library.yale.edu/ysmpa_theses/194
