Date of Award

Summer 8-25-2023

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

James Clune, MD


Background: Current guidelines recommend SLN biopsy (SLNB) among patients with initial Breslow Thickness (BRES) ≥0.8mm at initial screening. However, there is limited guidance regarding SLNB among patients who have deeper final depth after initial biopsy.

Methods: We conducted a retrospective cohort study of 62 thin melanoma patients with primary lesions with initial Breslow Thickness (BRES)

Results: Approximately 55% of patients (n = 34) included in our study underwent SLNB. After adjustment, there was no association between SLNB status and recurrence. Immunosuppressive drug use was associated with higher odds of local (OR= 28.56 CI 1.87- 435.53; p =0.016) and regional recurrence (OR= 28.55 CI 1.5–542.50; p =0.016). Smoking was also associated with higher odds of regional recurrence (OR= 18.48 CI 1.37-249.15; p =0.028). Lymphocytic infiltrate was associated with lower odds of regional (OR= 0.05 CI 0.004-0.70; p =0.03) and distant (OR= 0.97 CI 0.01–0.71; p =0.02) recurrence.

Conclusions: Among patients with initial Breslow Thickness (BRES)

Open Access

This Article is Open Access