Date of Award

Summer 6-16-2023

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Srinivas Muvvala, MD, MPH


Naltrexone is a full opioid antagonist approved for the treatment of alcohol use disorder that can effectively reduce alcohol consumption. There are few studies that study the impact of starting naltrexone for alcohol use disorder in the inpatient setting. We propose to compare rates of outpatient treatment follow-up for alcohol use disorder in hospitalized patients who are referred to treatment without initiating naltrexone versus those initiated on oral naltrexone or injectable naltrexone. Using an open-label, randomized clinical trial design, we will enroll 75 adults aged 18 to 55 with alcohol use disorder admitted to a general medicine inpatient service and track their follow-up with outpatient treatment. This study will provide insight on the impact of initiating naltrexone for alcohol use disorder in the inpatient setting and on linkage to outpatient care.

Open Access

This Article is Open Access