Date of Award

Spring 3-24-2023

Document Type


Degree Name

Master of Medical Science (MMSc)

First Advisor

Robert McNamara, MD, MHS


Beta blockers are essential in the treatment of Heart Failure with Reduced Ejection Fraction. For this patient population, the benefits of beta blocker treatment, including decrease in all-cause mortality, are optimal when given at a target dose. In clinical practice, beta blocker dosing is rarely maximized because of concern for associated side effects, including bradycardia. Systematic strategies for achieving target beta blocker dosage are not well explored.

In this randomized controlled trial, we will compare the use of continuous remote patient-generated data from an Apple Watch to maximize titration of beta blocker medications with the target dose within 6 months. We hypothesize this change from the current follow-up practice of obtaining single time point vital signs at in-person office visits will increase the percentage of target beta blocker dosages prescribed in patients with heart failure with reduced ejection fraction.