The Effect of Platelet-Rich Plasma on Recovery in Athletes with a Grade III Lateral Ankle Sprain
Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Sean Peden, MD
Lateral ankle sprains are the most common cause of missed athletic participation. One emerging therapy that has been used to hasten recovery from orthopedic injuries is injection with platelet-rich plasma. However, the effect of platelet-rich plasma on recovery from lateral ankle sprains has only been studied in the context of less severe injuries (grades one and two). We hypothesize that a platelet-rich plasma injection will decrease the mean days to return to play in athletes with a severe (grade three) lateral ankle sprain. We will conduct a multicenter randomized controlled trial to investigate the mean days to return to play in athletes with a grade three lateral ankle sprain who receive a platelet-rich plasma injection compared to a placebo injection. The study findings may indicate an adjuvant therapy that can improve outcomes and reduce unnecessary surgical intervention in a very common athletic injury.
Attolino, Matthew, "The Effect of Platelet-Rich Plasma on Recovery in Athletes with a Grade III Lateral Ankle Sprain" (2022). Yale School of Medicine Physician Associate Program Theses. 116.
Available for download on Monday, May 20, 2024
This Article is Open Access