Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Sean Peden, MD


Lateral ankle sprains are the most common cause of missed athletic participation. One emerging therapy that has been used to hasten recovery from orthopedic injuries is injection with platelet-rich plasma. However, the effect of platelet-rich plasma on recovery from lateral ankle sprains has only been studied in the context of less severe injuries (grades one and two). We hypothesize that a platelet-rich plasma injection will decrease the mean days to return to play in athletes with a severe (grade three) lateral ankle sprain. We will conduct a multicenter randomized controlled trial to investigate the mean days to return to play in athletes with a grade three lateral ankle sprain who receive a platelet-rich plasma injection compared to a placebo injection. The study findings may indicate an adjuvant therapy that can improve outcomes and reduce unnecessary surgical intervention in a very common athletic injury.

Available for download on Monday, May 20, 2024

Open Access

This Article is Open Access