Date of Award


Document Type


Degree Name

Medical Doctor (MD)



First Advisor

Jeffrey M. Cohen


There is incomplete understanding of the association of atopic dermatitis (AD) with neuropsychiatric disorders. This case-control study using the National Institutes of Health All of Us Research Program database aims to evaluate the odds of various neuropsychiatric conditions in patients with AD in a large, diverse cohort of adults in the United States. Comorbidities were compared between cases and controls using statistical hypothesis testing and odds ratios were generated using logistic regression in univariable and multivariable analyses.

In a cohort of 13,433 AD cases with 53,732 matched controls (4:1), patients with AD were more likely to have a diagnosis of alcohol use disorder, attention deficit hyperactivity disorder, schizophrenia, schizoaffective disorder, bipolar disorder, and obsessive-compulsive disorder (all P

This study confirms that AD is associated with increased odds of various neuropsychiatric disorders even after controlling for demographics and common comorbidities. Dermatologists and other healthcare providers treating patients with AD should be aware of these associations and conduct appropriate mental health screenings and referrals to other providers when appropriate.


This thesis is restricted to Yale network users only. It will be made publicly available on 06/30/2024