Date of Award
1-1-2016
Document Type
Open Access Thesis
Degree Name
Medical Doctor (MD)
Department
Medicine
First Advisor
Richard Edelson
Abstract
Extracorporeal Photochemotherapy (ECP) is a widely used immunotherapy for cutaneous T cell lymphoma, as well as an immunomodulatory treatment for graft versus host disease (GVHD) and rejection of allografts. We hypothesized that ECP’s physiologic induction of large-scale monocyte-to-dendritic antigen presenting cell (APC) conversion is mechanistically responsible for both its anti-cancer effect and its tolerogenic impact in the transplant setting. To interrogate this possibility in an experimental system, we developed an ECP device that is scalable from mouse to man and tested its capacity to produce APCs that, when advantageously tuned and tumor antigen-loaded, can limit the growth of otherwise lethal tumors in the engineered Yale University Mouse Melanoma (YUMM) 1.7 model (driven by PTEN loss, BRAFV600E activation and CDKN2A mutations). Untreated control mouse tumors (N=169) were 7 to 10-fold (p
Recommended Citation
Vassall, Aaron Nathaniel, "Modified Extracorporeal Photopheresis As An Immunotherapy In Murine Melanoma" (2016). Yale Medicine Thesis Digital Library. 2089.
https://elischolar.library.yale.edu/ymtdl/2089
Comments
This is an Open Access Thesis.