Date of Award

January 2015

Document Type


Degree Name

Medical Doctor (MD)



First Advisor

David J. Leffell

Second Advisor

Robert E. Tigelaar

Subject Area(s)

Medicine, Oncology


Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE). We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs. We identified 22 subjects with 4 or more biopsy diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment and clinical outcome of each LE SCC were recorded. Of the 22 subjects studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCC in these subjects was over four times greater than the incidence of BCC. LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.


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