Date of Award

January 2013

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)



First Advisor

Marietta Vázquez

Subject Area(s)

Medicine, Virology


Assessment of H1N1 vaccine effectiveness in preventing hospitalization in children

Felicity Lenes-Voit, Alexandra P. Grizas, Novagrami George, Nancy Holabird, Rebekah Stein and Marietta Vázquez. Department of Pediatrics. Yale School of Medicine. New Haven, CT.


In 2009, the first influenza epidemic of the new millennium emerged. H1N1 disproportionately infected, hospitalized and killed pediatric patients, but the bulk of research on effective prevention was centered on the adult population. In order to address this gap, we conducted a matched case-control study to investigate the effectiveness of H1N1 vaccination in preventing hospitalization due to influenza-related illness in children and adolescents aged 6 months to 17 years of age. We found that one dose of H1N1 vaccine is only 30.5% effective in protecting against hospitalization for H1N1 influenza and identified several risk factors for an increased likelihood of hospitalization for influenza that can be used to guide future immunization policy.


This is an Open Access Thesis.

Open Access

This Article is Open Access