Date of Award

Spring 2021

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Crawford, Jason

Abstract

The microbiome encodes for a complex web of metabolites of which scientists are just starting to deconvolute. While a lot of focus has been on investigating the implications of the microbial metabolome on health and disease physiologies, we have merely uncovered the tip of the interactome of microbes and host G-Protein Coupled Receptors (GPCRs). Early literature has reported a plethora of short chain fatty acids fermented by dietary fibers acting as GPCR agonists. A few other studies have showcased that gut microbes produced N-acyl amides and secondary bile acids mimicking host ligands and therefore interacting with these GPCRs. Chapter 2 and 3 showcases the different strategies to mine GPCR agonists from the commensal microbiota.

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