Title

Homogeneous Organic Electron Donors in Transition Metal-Catalyzed Reductive Coupling Reactions

Date of Award

Fall 10-1-2021

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Hazari, Nilay

Abstract

This thesis summarizes work towards understanding the mechanism of and improving upon nickel-catalyzed reductive coupling reactions through the use of homogeneous organic reductants and understanding of the fundamental reactivity of nickel intermediates. Chapter 1 presents an overview of the utility of homogeneous organic electron donors in nickel-catalyzed reductive coupling reactions. Chapter 2 provides a mechanistic investigation into the nickel-catalyzed carboxylation of aryl halides with carbon dioxide using a homogeneous organic electron donor. In Chapter 3, a general strategy for the cross-electrophile coupling of aryl and alkyl halides is explored. In Chapter 4, the reactivity of a nickel hydride complex supported by a pincer scaffold is explored with small molecules such as N2 and CO.

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