Homogeneous Organic Electron Donors in Transition Metal-Catalyzed Reductive Coupling Reactions
Date of Award
Doctor of Philosophy (PhD)
This thesis summarizes work towards understanding the mechanism of and improving upon nickel-catalyzed reductive coupling reactions through the use of homogeneous organic reductants and understanding of the fundamental reactivity of nickel intermediates. Chapter 1 presents an overview of the utility of homogeneous organic electron donors in nickel-catalyzed reductive coupling reactions. Chapter 2 provides a mechanistic investigation into the nickel-catalyzed carboxylation of aryl halides with carbon dioxide using a homogeneous organic electron donor. In Chapter 3, a general strategy for the cross-electrophile coupling of aryl and alkyl halides is explored. In Chapter 4, the reactivity of a nickel hydride complex supported by a pincer scaffold is explored with small molecules such as N2 and CO.
Charboneau, David John, "Homogeneous Organic Electron Donors in Transition Metal-Catalyzed Reductive Coupling Reactions" (2021). Yale Graduate School of Arts and Sciences Dissertations. 312.