Title

Structural and Functional Characterization of Lipid-Derived Molecules From the Human Microbiome

Date of Award

Spring 2021

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Crawford, Jason

Abstract

Scientific evidence for the contribution of the human microbiome to the promotion of human health and disease has been rapidly accumulating. With advances in sequencing technologies and bioinformatics, more specific correlations can be made between certain bacterial strains and/or their genes to specific disease phenotypes. However, the molecular mechanisms by which bacteria are able to influence human health remains largely elusive. Bacteria are known to interact with their environment by production and modulation of small molecules. Bacterially-produced lipid-derived molecules play important signaling roles and modulate eukaryotic cellular responses through the activation of various receptors.

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