Correlation Between Mendelian Rescessive Traits and the Resistance to Fibrosarcoma in Mice

Author

Frank Louis Gruskay, Yale University

Date of Award

1-1-1954

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Dr. Leonell C. Strong

Abstract

[From the Summary] 1. A correlation between tumor resistance, as measured by the latency period and the percentage of animals acquiring tumors, and the number of recessive genes in the genotypic makeup has been investigated with methylcholanthrene-induced tumors in mice. 2. Evidence is presented which points to the fact that recessive genes impart more resistance than dominant ones. In addition, the relationship seems to be an additive phenomenon, i.e., the more recessive genes in the makeup of the animal, the greater the resistance. 3. The results of this study are discussed in light of the findings of various other investigators, and these seem to fit in well with their findings. 4. A speculative hypothesis of mechanism is presented and discussed.

Comments

This is an Open Access Thesis.

Recommended Citation

Gruskay, Frank Louis, "Correlation Between Mendelian Rescessive Traits and the Resistance to Fibrosarcoma in Mice" (1954). Yale Medicine Thesis Digital Library. 496.
https://elischolar.library.yale.edu/ymtdl/496