Date of Award

2-23-2009

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Mert O. Bahtiyar

Abstract

The purpose of this study was to determine whether there is an association between chorionic villus sampling for prenatal diagnosis and the development of hypertensive disorders of pregnancy. This study is a single-site retrospective case control study using medical records of patients seen at Yale-New Haven Hospital. A total of 448 patients in three groups (first trimester aneuploidy screening with nuchal translucency assessment, genetic amniocentesis, and chorionic villus sampling) were included and data on maternal characteristics, delivery outcomes, risk factors, and hypertensive outcomes were recorded. Unadjusted odds ratios and odds ratios adjusted for maternal age and race were calculated to compare the probability of gestational hypertension and preeclampsia between the groups using the nuchal translucency group as the control. In the genetic amniocentesis group, the adjusted odds ratio for gestational hypertension was 1.9 (95% CI 0.2 - 170.1) and the ratio for preeclampsia was 1.4 (95% CI 0.19 - 5.80), both statistically not significant. In the chorionic villus sampling group, the adjusted odds ratio for gestational hypertension was 0.4 (95% CI 0.03 - 4.7) and the ratio for preeclampsia was 0.93 (95% CI 0.8 - 1.07), again both statistically not significant. This study concluded that there is no association between chorionic villus sampling and the development of hypertensive disorders of pregnancy.

Comments

This is an Open Access Thesis.

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