Date of Award

January 2011

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Richard Peschel

Subject Area(s)

Medicine

Abstract

Purpose

To determine whether differences exist in biochemical disease-free survival (BDFS) and acute toxicity between African-American (AA) and non-Latino white (NLW) men with prostate cancer treated with intensity modulated radiation therapy (IMRT).

Methods and Materials

Between January 2000 and January 2008, 129 AA and 591 NLW men with clinically localized prostate cancer were treated with IMRT. Median follow up was 26.6 months for both groups. Kaplan-Meier analysis was used to compute rates of biochemical disease free survival. Chi-square analysis was used to compute rates of acute toxicity.

Results

No difference was found in three year biochemical disease free survival (BDFS) rates between AA vs. NLW men, p= 0.71. Three year BDFS rates were 92% for NLW men vs. 89% for AA men. Multivariate analysis showed that race was not an important predictor of BDFS (p=0.88), while the variables PSA (p=0.003) and Gleason score (p=0.01) were. AA men had a significantly lower rate of gastrointestinal (GI) toxicity of grade 2 than NLW men (p=0.014), 6% vs. 13%, respectively.

Conclusions

Our study shows no difference in BDFS rates between AA and NLW men treated with IMRT. AA men had a lower rate of grade 2 GI toxicity than NLW men.

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