Date of Award

January 2021

Document Type

Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Yong Zhu

Abstract

Over the past decade, many studies have found disproportionally higher prostate cancer among men of African ancestry, and testicular cancer incidences among men of European ancestry, compared with men from other ethnicity/race groups. However, genetic determinants that could potentially explain this observation are unclear. This study collected single nucleotide polymorphisms (SNPs) related to the two cancer types and compared the frequencies of each risk allele of SNPs among men of African or European ancestry from several genetic databases. When comparing the frequencies of risk alleles that are associated with prostate and testicular cancers, significant differences were found between those of African descendants and European descendants. As the second part of this thesis, we investigated the roles of genetic in the reversal relationship observed between asthma and all cancer risks. Single Nucleotide Polymorphisms that were reported to be associated with asthma were collected and identified first and the cancer risks related to each variant were reviewed in the hope to provide genetic basis for future pathway analysis.

Comments

This thesis is restricted to Yale network users only. It will be made publicly available on 06/01/2022

Share

COinS