Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
Adrian Maung, MD, FACS, FCCM
Trauma is the leading cause of death for people between 0 and 45 years of age. An important step in the management of trauma patients is the replacement of a large volume of fluids, typically with normal saline. However, normal saline has been implicated in the development of metabolic derangements that may contribute to a large proportion of deaths in trauma patients. In this study, we will examine whether less acidic solutions that contain buffers can improve survival in trauma patients compared to normal saline. We will perform a double-blind randomized control trial to determine whether fluid replacement with Lactated Ringer's solution or a solution of 0.45% normal saline and sodium bicarbonate in a prehospital setting can improve survival in trauma patients compared to normal saline. The insights gleaned from this study could dramatically alter the management of trauma patients and save countless lives.
Murphy, David Seth, "Back to Basics: The Effects of Buffered Crystalloids on Mortality in the Setting of Severe Trauma" (2021). Yale School of Medicine Physician Associate Program Theses. 91.
This Article is Open Access