Date of Award


Document Type


Degree Name

Master of Medical Science (MMSc)

First Advisor

Pinar Kodaman, MD, PhD


Polycystic ovary syndrome is the most common endocrinopathy in females of reproductive age, affecting around 5-10% of women worldwide. While the exact etiology of polycystic ovary syndrome is unknown, insulin resistance is present in a large percentage of affected women. Lifestyle modifications including diet and exercise are the first-line therapy recommended to patients to help manage insulin resistance. However, there is no clear consensus whether exercise alone or in combination with diet offers the greatest reduction in insulin resistance. In this study, we will assess the effect of strength training, low-carbohydrate diet, or a combination approach in women with polycystic ovary syndrome. Specifically, we will use a randomized controlled trial to measure mean changes in homeostatic model assessment of insulin resistance before and after intervention. This work will help providers to better advise this population on management of insulin resistance to prevent future cardiometabolic sequelae.