Title

Injection Site Massage to Improve the Pharmacokinetics of Aspart in Obese Adolescents with Diabetes

Date of Award

5-14-2014

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Eda Cengiz, MD, MHS, FAAP

Abstract

The invention of rapid-acting insulin analogs, such as aspart, was a great step forward in achieving optimal control of blood glucose in patients with type 1 diabetes. Aspart’s action resembles the physiologic endogenous post-meal insulin action; however, the slow rate of absorption through subcutaneous tissue leads to a delay in the time to peak levels and action of pre-meal insulin injection and suboptimal control of postprandial blood glucose excursions. We propose that massaging the site of aspart injection will significantly accelerate insulin action and mitigate postprandial blood glycemic excursions. The study will investigate the effect of injection site massage on the pharmacokinetics and pharmacodynamics of subcutaneously administered aspart in overweight and obese adolescents with type 1 diabetes who are at high-risk for impaired insulin action. Massage will offer a cost effective solution to the undesired postprandial glycemic excursions that directly and indirectly contribute to mortality and morbidity associated with diabetes.

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Open Access

This Article is Open Access

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